Monocytotoxic antibodies after bone marrow transplantation in aplastic anemia

J. C. Gluckman, E. Gluckman, O. Azogui, J. Guillet, W. M. Baldwin, A. Devergie, F. Chapuis, E. Brisson, E. Andersen, J. Dausset

Research output: Contribution to journalArticlepeer-review

Abstract

Pre- and post-transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted only to M and appeared to recognize non-HLA M-associated antigens. No significant reaction to endothelial cells was obtained with these sera. The subsequent clinical course was not associated with any reaction pattern of pretransplant sera. There was a significant relationship between rejection and the development of M antibodies after grafting, but since these were also found in many other patients without rejection, their occurrence has no predictive value for an individual patient.

Original languageEnglish (US)
Pages (from-to)599-602
Number of pages4
JournalTransplantation
Volume33
Issue number6
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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