Monocyte chemoattractant protein-1 immunoreactivity in sensory ganglia and hindpaw after adjuvant injection

Sang Min Jeon, Kyung Min Lee, Eun Sung Park, Young Hoon Jeon, Hee Jung Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a member of the CC chemokine family that exhibits potent chemotactic activity for monocytes/macrophages. In the current study, the proportion of monocyte chemoattractant protein-1-immunoreactive (IR) neurons in the dorsal root ganglion (DRG) of rats was shown to increase markedly following adjuvant injection into the hindpaw. MCP-1-IR axon terminals were not found in the spinal cord or hindpaw of control or adjuvant-treated rats. Instead, the inflamed hindpaw dermis was infiltrated by numerous MCP-1-IR inflammatory cells. Following adjuvant injection, the majority of MCP-1-IR neurons in the DRG colocalized with IB4 binding. Our findings suggest that peripheral tissue inflammation induces increased MCP-1 expression in DRG neurons and this may be dependent upon glial cell line-derived neurotrophic factor.

Original languageEnglish (US)
Pages (from-to)183-186
Number of pages4
JournalNeuroreport
Volume19
Issue number2
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • Dorsal root ganglion
  • Hindpaw
  • Immunohistochemistry
  • Monocyte chemoattractant protein-1
  • Pain
  • Spinal cord
  • trkA

ASJC Scopus subject areas

  • Neuroscience(all)

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