TY - JOUR
T1 - Monocyte Activation Is Associated With Worse Cognitive Performance in HIV-Infected Women With Virologic Suppression
AU - Imp, Brandon M.
AU - Rubin, Leah H.
AU - Tien, Phyllis C.
AU - Plankey, Michael W.
AU - Golub, Elizabeth T.
AU - French, Audrey L.
AU - Valcour, Victor G.
N1 - Funding Information:
Financial support. This work was supported by the National Institutes of Health (grant K24-MH-098759 to V. G. V.), the National Institute of Allergy and Infectious Diseases (grants UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590 to the WIHS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant UO1-HD-32632 to the WIHS), the National Cancer Institute (to the WIHS), the National Institute on Drug Abuse (to the WIHS), the National Institute on Deafness and Other Communication Disorders (to the WIHS), the National Center for Research Resources (UCSF-CTSI grant UL1 RR024131 to the WIHS), the National Institute of Mental Health (grant K01-MH-098798 to L. H. R.), and the National Institute of Allergy and Infectious Diseases (grant K24 AI 108516 to P. C. T.).
Publisher Copyright:
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background. Cognitive impairment persists despite suppression of plasma human immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely mechanism. We examined immune activation and cognition in a cohort of HIV-infected and uninfected women from the Women’s Interagency HIV Study (WIHS). Methods. Blood levels of activation markers, soluble CD163 (sCD163), soluble CD14 (sCD14), CRP, IL-6, and a gut microbial translocation marker (intestinal fatty acid binding protein (I-FABP)) were measured in 253 women (73% HIV-infected). Markers were compared to concurrent (within ± one semiannual visit) neuropsychological testing performance. Results. Higher sCD163 levels were associated with worse overall performance and worse verbal learning, verbal memory, executive function, psychomotor speed, and fine motor skills (P < .05 for all comparisons). Higher sCD14 levels were associated with worse verbal learning, verbal memory, executive function, and psychomotor speed (P < .05 for all comparisons). Among women with virological suppression, sCD163 remained associated with overall performance, verbal memory, psychomotor speed, and fine motor skills, and sCD164 remained associated with executive function (P < .05 for all comparisons). CRP, IL-6, and I-FABP were not associated with worse cognitive performance. Conclusions. Monocyte activation was associated with worse cognitive performance, and associations persisted despite viral suppression. Persistent inflammatory mechanisms related to monocytes correlate to clinically pertinent brain outcomes.
AB - Background. Cognitive impairment persists despite suppression of plasma human immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely mechanism. We examined immune activation and cognition in a cohort of HIV-infected and uninfected women from the Women’s Interagency HIV Study (WIHS). Methods. Blood levels of activation markers, soluble CD163 (sCD163), soluble CD14 (sCD14), CRP, IL-6, and a gut microbial translocation marker (intestinal fatty acid binding protein (I-FABP)) were measured in 253 women (73% HIV-infected). Markers were compared to concurrent (within ± one semiannual visit) neuropsychological testing performance. Results. Higher sCD163 levels were associated with worse overall performance and worse verbal learning, verbal memory, executive function, psychomotor speed, and fine motor skills (P < .05 for all comparisons). Higher sCD14 levels were associated with worse verbal learning, verbal memory, executive function, and psychomotor speed (P < .05 for all comparisons). Among women with virological suppression, sCD163 remained associated with overall performance, verbal memory, psychomotor speed, and fine motor skills, and sCD164 remained associated with executive function (P < .05 for all comparisons). CRP, IL-6, and I-FABP were not associated with worse cognitive performance. Conclusions. Monocyte activation was associated with worse cognitive performance, and associations persisted despite viral suppression. Persistent inflammatory mechanisms related to monocytes correlate to clinically pertinent brain outcomes.
KW - CD14
KW - CD163
KW - HIV infection
KW - cognition disorders
KW - intesticial fatty acid-binding protein (1-19)
KW - women
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U2 - 10.1093/INFDIS/JIW506
DO - 10.1093/INFDIS/JIW506
M3 - Article
C2 - 27789726
AN - SCOPUS:85020255362
VL - 215
SP - 114
EP - 121
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -