Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland

Sylvia L. Van Egmond, Wendy W J De Leng, Folkert H M Morsink, G. Johan A Offerhaus, Lodewijk A A Brosens

Research output: Contribution to journalArticlepeer-review

Abstract

Primary multiple pleomorphic adenomas in a unilateral parotid gland in previously untreated patients is a rare finding, and little is known about the etiology and pathogenesis. Here, a highly unusual case of a primary multifocal pleomorphic adenoma consisting of 15 individual nodules is presented. It is shown that all nodes are clonally related and thus share a common cell of origin excluding an independent multifocal pathogenesis. Most likely, multifocal pleomorphic adenoma represents parasitic nodules that have been detached from a main nodule, which may have been the result of undisclosed trauma.

Original languageEnglish (US)
Pages (from-to)923-926
Number of pages4
JournalHuman Pathology
Volume44
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Keywords

  • Humara
  • Monoclonal
  • Multifocal
  • Parotid gland
  • Pleomorphic adenoma
  • X-chromosome inactivation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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