Monoclonal immunoglobulin-secreting lymphoma in a patient with severe combined immunodeficiency disease

L. R. Shirley, R. H. Buckley, M. J. Borowitz, S. I. Welt, D. D. Kostyu

Research output: Contribution to journalArticle

Abstract

A 3.5 year old boy with X-linked severe combined immunodeficiency disease (SCID), who had been in laminar flow isolation throughout his life, developed a B cell tumour producing up to 3008 mg/dl of an IgM(k) paraprotein 1 month after infusion of both liver and thymus cells from a fetal donor and 6 months after the last of six fetal liver cell infusions given over a 3 year period. Pretransplant studies revealed a high percentage of circulating B lymphocytes. HLA typing suggests that the tumour was of host origin.

Original languageEnglish (US)
Pages (from-to)666-674
Number of pages9
JournalClinical and Experimental Immunology
Volume48
Issue number3
StatePublished - 1982

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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