MONOCLONAL CHARACTERISTICS OF ORGANISING ARTERIAL THROMBI: SIGNIFICANCE IN THE ORIGIN AND GROWTH OF HUMAN ATHEROSCLEROTIC PLAQUES

Thomas A. Pearson, John Dillman, Kim Solez, Robert H. Heptinstall

Research output: Contribution to journalArticle

Abstract

The clonal characteristics of 26 arterial thrombi at different stages of organisation were determined using the X-linked enzyme, glucose-6-phosphate dehydrogenase (G.-6-P.D.), as a clonal marker in 13 women heterozygous for electrophoretically separable G.-6-P.D. isoenzymes. A gradation of increasing monoclonality was observed with increasing organisation of the thrombi, such that only 21% of poorly organised (red) thrombi displayed monoclonal characteristics similar to those of atherosclerotic plaques, whereas 78% of moderately organised (pink) thrombi and 91% of well-organised (white) thrombi showed such characteristics. These results provide objective evidence for the role of thrombosis in the formation of human atherosclerotic plaques.

Original languageEnglish (US)
Pages (from-to)7-11
Number of pages5
JournalThe Lancet
Volume313
Issue number8106
DOIs
StatePublished - Jan 6 1979

ASJC Scopus subject areas

  • Medicine(all)

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