TY - JOUR
T1 - MONOCLONAL CHARACTERISTICS OF ORGANISING ARTERIAL THROMBI
T2 - SIGNIFICANCE IN THE ORIGIN AND GROWTH OF HUMAN ATHEROSCLEROTIC PLAQUES
AU - Pearson, Thomas A.
AU - Dillman, John
AU - Solez, Kim
AU - Heptinstall, Robert H.
N1 - Funding Information:
This work was supported in Public Health Service.
Funding Information:
cal abnormality appears to be a &bgr;-N.G.F. species which is present in normal concentrations, as determined by the antigenic assay, but shows increased functional activity (see table). In central neurofibromatosis, on the other hand, the defect appears to lie in an overproduction of a 3-N.G.F. which shows low-to-normal function. The further characterisation of such molecular species in neurofibromatosis may provide avenues for future diag- noses and possible treatments. We thank Linda Toler, Estelle Harvey, Janice Koci, and Gail Fabri- cant for excellent technical assistance, Dr Stephen Sherwin for helpful suggestions, and Patricia Johnson for preparing the manuscript. This work was supported in part by the Virus Cancer Program. Requests for reprints should be addressed to G. J. T.
PY - 1979/1/6
Y1 - 1979/1/6
N2 - The clonal characteristics of 26 arterial thrombi at different stages of organisation were determined using the X-linked enzyme, glucose-6-phosphate dehydrogenase (G.-6-P.D.), as a clonal marker in 13 women heterozygous for electrophoretically separable G.-6-P.D. isoenzymes. A gradation of increasing monoclonality was observed with increasing organisation of the thrombi, such that only 21% of poorly organised (red) thrombi displayed monoclonal characteristics similar to those of atherosclerotic plaques, whereas 78% of moderately organised (pink) thrombi and 91% of well-organised (white) thrombi showed such characteristics. These results provide objective evidence for the role of thrombosis in the formation of human atherosclerotic plaques.
AB - The clonal characteristics of 26 arterial thrombi at different stages of organisation were determined using the X-linked enzyme, glucose-6-phosphate dehydrogenase (G.-6-P.D.), as a clonal marker in 13 women heterozygous for electrophoretically separable G.-6-P.D. isoenzymes. A gradation of increasing monoclonality was observed with increasing organisation of the thrombi, such that only 21% of poorly organised (red) thrombi displayed monoclonal characteristics similar to those of atherosclerotic plaques, whereas 78% of moderately organised (pink) thrombi and 91% of well-organised (white) thrombi showed such characteristics. These results provide objective evidence for the role of thrombosis in the formation of human atherosclerotic plaques.
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U2 - 10.1016/S0140-6736(79)90453-7
DO - 10.1016/S0140-6736(79)90453-7
M3 - Article
C2 - 83516
AN - SCOPUS:0018343798
SN - 0140-6736
VL - 313
SP - 7
EP - 11
JO - The Lancet
JF - The Lancet
IS - 8106
ER -