Abstract
Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 379-383 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 500 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Oct 23 1989 |
| Externally published | Yes |
Fingerprint
Keywords
- Monoclonal antibody
- Neuroimmunology
- Neuropathology
- Schizophrenia
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Developmental Biology
- Clinical Neurology
Cite this
Monoclonal antibodies to study the brain in schizophrenia. / Honer, William G.; Kaufmann, Charles A.; Kleinman, Joel; Casanova, Manuel F.; Davies, Peter.
In: Brain Research, Vol. 500, No. 1-2, 23.10.1989, p. 379-383.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Monoclonal antibodies to study the brain in schizophrenia
AU - Honer, William G.
AU - Kaufmann, Charles A.
AU - Kleinman, Joel
AU - Casanova, Manuel F.
AU - Davies, Peter
PY - 1989/10/23
Y1 - 1989/10/23
N2 - Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.
AB - Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.
KW - Monoclonal antibody
KW - Neuroimmunology
KW - Neuropathology
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0024441796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024441796&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(89)90335-1
DO - 10.1016/0006-8993(89)90335-1
M3 - Article
C2 - 2605504
AN - SCOPUS:0024441796
VL - 500
SP - 379
EP - 383
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -