Monoclonal antibodies to study the brain in schizophrenia

William G. Honer; Charles A. Kaufmann; Joel E. Kleinman; Manuel F. Casanova; Peter Davies

doi:10.1016/0006-8993(89)90335-1

Monoclonal antibodies to study the brain in schizophrenia

William G. Honer, Charles A. Kaufmann, Joel E. Kleinman, Manuel F. Casanova, Peter Davies

Research output: Contribution to journal › Article › peer-review

Abstract

Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.

Original language	English (US)
Pages (from-to)	379-383
Number of pages	5
Journal	Brain research
Volume	500
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(89)90335-1
State	Published - Oct 23 1989
Externally published	Yes

Keywords

Monoclonal antibody
Neuroimmunology
Neuropathology
Schizophrenia

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(89)90335-1

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title = "Monoclonal antibodies to study the brain in schizophrenia",

abstract = "Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.",

keywords = "Monoclonal antibody, Neuroimmunology, Neuropathology, Schizophrenia",

author = "Honer, {William G.} and Kaufmann, {Charles A.} and Kleinman, {Joel E.} and Casanova, {Manuel F.} and Peter Davies",

note = "Funding Information: This work was supportedb y a NARSAD Fellowship to W.G.H. and by the MetropolitanL ife Foundation.",

year = "1989",

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doi = "10.1016/0006-8993(89)90335-1",

language = "English (US)",

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pages = "379--383",

journal = "Brain Research",

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T1 - Monoclonal antibodies to study the brain in schizophrenia

AU - Honer, William G.

AU - Kaufmann, Charles A.

AU - Kleinman, Joel E.

AU - Casanova, Manuel F.

AU - Davies, Peter

N1 - Funding Information: This work was supportedb y a NARSAD Fellowship to W.G.H. and by the MetropolitanL ife Foundation.

PY - 1989/10/23

Y1 - 1989/10/23

N2 - Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.

AB - Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.

KW - Monoclonal antibody

KW - Neuroimmunology

KW - Neuropathology

KW - Schizophrenia

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SN - 0006-8993

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ER -

Monoclonal antibodies to study the brain in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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