Monoclonal antibodies to study the brain in schizophrenia

William G. Honer, Charles A. Kaufmann, Joel Kleinman, Manuel F. Casanova, Peter Davies

Research output: Contribution to journalArticle

Abstract

Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalBrain Research
Volume500
Issue number1-2
DOIs
StatePublished - Oct 23 1989
Externally publishedYes

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Schizophrenia
Monoclonal Antibodies
Brain
Antibodies

Keywords

  • Monoclonal antibody
  • Neuroimmunology
  • Neuropathology
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Honer, W. G., Kaufmann, C. A., Kleinman, J., Casanova, M. F., & Davies, P. (1989). Monoclonal antibodies to study the brain in schizophrenia. Brain Research, 500(1-2), 379-383. https://doi.org/10.1016/0006-8993(89)90335-1

Monoclonal antibodies to study the brain in schizophrenia. / Honer, William G.; Kaufmann, Charles A.; Kleinman, Joel; Casanova, Manuel F.; Davies, Peter.

In: Brain Research, Vol. 500, No. 1-2, 23.10.1989, p. 379-383.

Research output: Contribution to journalArticle

Honer, WG, Kaufmann, CA, Kleinman, J, Casanova, MF & Davies, P 1989, 'Monoclonal antibodies to study the brain in schizophrenia', Brain Research, vol. 500, no. 1-2, pp. 379-383. https://doi.org/10.1016/0006-8993(89)90335-1
Honer, William G. ; Kaufmann, Charles A. ; Kleinman, Joel ; Casanova, Manuel F. ; Davies, Peter. / Monoclonal antibodies to study the brain in schizophrenia. In: Brain Research. 1989 ; Vol. 500, No. 1-2. pp. 379-383.
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