Monoclonal antibodies to study the brain in schizophrenia

William G. Honer, Charles A. Kaufmann, Joel E. Kleinman, Manuel F. Casanova, Peter Davies

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Twelve monoclonal antibodies were developed which show selective reactivity with brain tissue homogenates from 4 patients with schizophrenia compared to 4 normal controls. Certain antibodies were more reactive with tissue from cases with schizophrenia, others with control tissue. Patterns of reactivity also depended on brain region tested. Differences in reactivity generally ranged from 2- to as much as 8-fold. This panel of monoclonal antibodies may be useful to investigate the pathophysiology of schizophrenia.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalBrain research
Issue number1-2
StatePublished - Oct 23 1989
Externally publishedYes


  • Monoclonal antibody
  • Neuroimmunology
  • Neuropathology
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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