Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats

V. V. Sherstnev, Mikhail Pletnikov, Z. I. Storozheva, S. G. El'nikova, T. M. Pankova, M. V. Starostina, M. B. Shtark

Research output: Contribution to journalArticle

Abstract

Effect of monoclonal antibodies to A3G7 protein specific for cerebellar Purkinje cells and hippocampal pyramidal neurons on learning, consolidation, and retrieval of short-and long-term habituation to acoustic startle reaction is studied in adult rats. Application of 1 mg/ml antibodies to the cerebellar vermis selectively disturbs long-term habituation, while 2 mg/ml antibodies inhibit both short- and long-term habituation. The data are analyzed with consideration of the involvement of A3G7 protein into nerve growth and neurotransmittory processes underlying learning and memory in developing and mature brain.

Original languageEnglish (US)
Pages (from-to)813-815
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume126
Issue number8
StatePublished - Aug 1998
Externally publishedYes

Fingerprint

Nerve Tissue
Rats
Startle Reflex
Monoclonal Antibodies
Learning
Tissue
Data storage equipment
Antibodies
Pyramidal Cells
Purkinje Cells
Growth
Acoustics
Consolidation
Neurons
Brain
Proteins
Cerebellar Vermis

Keywords

  • Acoustic startle reaction
  • Learning
  • Memory
  • Monoclonal antibodies
  • Nerve growth factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Sherstnev, V. V., Pletnikov, M., Storozheva, Z. I., El'nikova, S. G., Pankova, T. M., Starostina, M. V., & Shtark, M. B. (1998). Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats. Bulletin of Experimental Biology and Medicine, 126(8), 813-815.

Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats. / Sherstnev, V. V.; Pletnikov, Mikhail; Storozheva, Z. I.; El'nikova, S. G.; Pankova, T. M.; Starostina, M. V.; Shtark, M. B.

In: Bulletin of Experimental Biology and Medicine, Vol. 126, No. 8, 08.1998, p. 813-815.

Research output: Contribution to journalArticle

Sherstnev, VV, Pletnikov, M, Storozheva, ZI, El'nikova, SG, Pankova, TM, Starostina, MV & Shtark, MB 1998, 'Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats', Bulletin of Experimental Biology and Medicine, vol. 126, no. 8, pp. 813-815.
Sherstnev, V. V. ; Pletnikov, Mikhail ; Storozheva, Z. I. ; El'nikova, S. G. ; Pankova, T. M. ; Starostina, M. V. ; Shtark, M. B. / Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats. In: Bulletin of Experimental Biology and Medicine. 1998 ; Vol. 126, No. 8. pp. 813-815.
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