Monoclonal antibodies in the diagnosis and treatment of human diseases

Research output: Contribution to journalArticle

Abstract

Monoclonal antibodies are being used as drugs in the diagnosis, prevention, and treatment of human diseases. The discipline of antibody engineering has evolved with modern cellular and molecular biology methods to meet the challenge of producing human monoclonal antibodies for in vivo biotherapy. In this overview, applications of monoclonal antibodies are presented for patients with selected diseases. Second, antibody engineering methods are overviewed from a chronological perspective for the production of therapeutic murine, human-like chimeric and CDR-grafted, and human monoclonal antibodies. Finally, safety considerations are examined for the efficacious use of monoclonal antibodies as diagnosis and therapeutic drugs.

Original languageEnglish (US)
Pages (from-to)575-581
Number of pages7
JournalAnnales de Biologie Clinique
Volume47
Issue number10
StatePublished - 1989

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human diseases
monoclonal antibodies
Monoclonal Antibodies
engineering
Cytology
Therapeutics
drugs
therapeutics
Biological Therapy
Molecular biology
antibodies
Antibodies
cell biology
Pharmaceutical Preparations
molecular biology
Cell Biology
Molecular Biology
Safety
mice
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

Cite this

Monoclonal antibodies in the diagnosis and treatment of human diseases. / Hamilton, Robert G.

In: Annales de Biologie Clinique, Vol. 47, No. 10, 1989, p. 575-581.

Research output: Contribution to journalArticle

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