Abstract
Five murine monoclonal antibodies (Mabs) reactive against the prM glycoproteins of DEN-3 and -4 were used to passively protect mice in vivo against lethal challenge with homologous and heterologous dengue virus serotypes. Four of the 5 prM-reactive monoclonals cross-protected mice against heterologous challenge, whereas 1 protected against challenge with only the homologous serotype. Although in vitro binding to virions was readily demonstrated, only 2 of the prM Mabs had detectable neutralizing activity. The neutralizing activity could not be enhanced by anti-mouse immunoglobulin or complement. However, 4 of the 5 prM Mabs fixed complement. This is the first report of prM-specific Mabs that are protective in mice.
Original language | English (US) |
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Pages (from-to) | 576-580 |
Number of pages | 5 |
Journal | American Journal of Tropical Medicine and Hygiene |
Volume | 41 |
Issue number | 5 |
DOIs | |
State | Published - 1989 |
ASJC Scopus subject areas
- Parasitology
- Virology
- Infectious Diseases