TY - JOUR
T1 - Monoamine oxidase A regulates antisocial personality in whites with no history of physical abuse
AU - Reti, Irving M.
AU - Xu, Jerry Z.
AU - Yanofski, Jason
AU - McKibben, Jodi
AU - Uhart, Magdalena
AU - Cheng, Yu Jen
AU - Zandi, Peter
AU - Bienvenu, Oscar J.
AU - Samuels, Jack
AU - Willour, Virginia
AU - Kasch-Semenza, Laura
AU - Costa, Paul
AU - Bandeen-Roche, Karen
AU - Eaton, William W.
AU - Nestadt, Gerald
N1 - Funding Information:
This research was supported by the following: National Institutes of Health grants RO1 MH050616-09 (Nestadt), RO1 MH47447 (Eaton), K23 MH64543 (Bienvenu), K23 AA017466 (Uhart), as well as the Intramural Research Program of the National Institute of Aging (Costa).
Funding Information:
Paul Costa receives royalties from the NEO-PI-R. Irving M. Reti receives research support from Brainsway, Inc, and Neuronetics Inc. Jerry Z. Xu, Jason Yanofski, Jodi McKibben, Magdalena Uhart, Yu-Jen Cheng, Peter Zandi, Oscar J. Bienvenu, Jack Samuels, Virginia Willour, Laura Kasch-Semenza, Karen Bandeen-Roche, William W. Eaton, and Gerald Nestadt report no biomedical financial interests or potential conflicts of interest.
PY - 2011/3
Y1 - 2011/3
N2 - Objective: Preclinical and human family studies clearly link monoamine oxidase A (MAOA) to aggression and antisocial personality (ASP). The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear. Methods: We evaluated the association of the variable number tandem repeat of the MAOA promoter with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ASP disorder (ASPD) traits in a community sample of 435 participants from the Hopkins Epidemiology of Personality Disorders Study. Results: We did not find an association between the activity of the MAOA allele and ASPD traits; however, among whites, when subjects with a history of childhood physical abuse were excluded, the remaining subjects with low-activity alleles had ASPD trait counts that were 41% greater than those with high-activity alleles (P < .05). Conclusion: The high-activity MAOA allele is protective against ASP among whites with no history of physical abuse, lending support to a link between MAOA expression and antisocial behavior.
AB - Objective: Preclinical and human family studies clearly link monoamine oxidase A (MAOA) to aggression and antisocial personality (ASP). The 30-base pair variable number tandem repeat in the MAOA promoter regulates MAOA levels, but its effects on ASP in humans are unclear. Methods: We evaluated the association of the variable number tandem repeat of the MAOA promoter with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ASP disorder (ASPD) traits in a community sample of 435 participants from the Hopkins Epidemiology of Personality Disorders Study. Results: We did not find an association between the activity of the MAOA allele and ASPD traits; however, among whites, when subjects with a history of childhood physical abuse were excluded, the remaining subjects with low-activity alleles had ASPD trait counts that were 41% greater than those with high-activity alleles (P < .05). Conclusion: The high-activity MAOA allele is protective against ASP among whites with no history of physical abuse, lending support to a link between MAOA expression and antisocial behavior.
UR - http://www.scopus.com/inward/record.url?scp=79551602291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551602291&partnerID=8YFLogxK
U2 - 10.1016/j.comppsych.2010.05.005
DO - 10.1016/j.comppsych.2010.05.005
M3 - Article
C2 - 21295226
AN - SCOPUS:79551602291
SN - 0010-440X
VL - 52
SP - 188
EP - 194
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
IS - 2
ER -