Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum

Nilabh Shastri, Niranjana Nagarajan, Kristin C. Lind, Takayuki Kanaseki

Research output: Contribution to journalReview article

Abstract

Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalCurrent Opinion in Immunology
Volume26
Issue number1
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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