Monitoring HPV type-specific prevalence over time through clinic-based surveillance: A perspective on vaccine effectiveness

N. H. Gaffga, E. W. Flagg, H. S. Weinstock, J. C. Shlay, K. G. Ghanem, L. A. Koutsky, P. R. Kerndt, K. K. Hsu, E. R. Unger, S. D. Datta

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the feasibility of monitoring trends in prevalence of vaccine-preventable human papillomavirus (HPV) types in different clinic populations. We collected cervical specimens from women presenting to family planning, primary care, and sexually transmitted disease (STD) clinics for routine pap smears in five US cities during 2003-2005. We performed HPV genotyping and calculated annual type-specific prevalences; pre-vaccine era prevalence was highest for HPV 16 (6.0; 95% confidence interval [CI] 5.5-6.6%) and annual prevalences for vaccine-preventable types were stable, with few exceptions, after controlling for clinic type, age group, and city. With sufficient sample size and stable population characteristics, clinic-based surveillance systems can contribute to monitoring HPV vaccine impact in the cervical screening population.

Original languageEnglish (US)
Pages (from-to)1959-1964
Number of pages6
JournalVaccine
Volume30
Issue number11
DOIs
StatePublished - Mar 2 2012

Keywords

  • Clinic-based surveillance
  • HPV
  • HPV vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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