Monitoring breath markers under controlled conditions

Marco Righettoni, Alessandro Ragnoni, Andreas T. Güntner, Claudio Loccioni, Sotiris E. Pratsinis, Terence H. Risby

Research output: Contribution to journalArticle

Abstract

Breath analysis has the potential to detect and monitor diseases as well as to reduce the corresponding medical costs while improving the quality of a patient's life. Herein, a portable prototype, consisting of a commercial breath sampler modified to work as a platform for solid-state gas sensors was developed. The sensor is placed close to the mouth (<10 cm) and minimizes the mouth-to-sensor path to avoid contamination and dilution of the target breath marker. Additionally with an appropriate cooling concept, even high sensor operating temperatures (e.g. 350°) could be used. Controlled sampling is crucial for accurate repeatable analysis of the human breath and these concerns have been addressed by this novel prototype. The device helps a subject control their exhaled flow rate which increases reproducibility of intra-subject breath samples. The operation of this flame-made selective chemoresistive gas sensor is demonstrated by the detection of breath acetone.

Original languageEnglish (US)
Article number047101
JournalJournal of breath research
Volume9
Issue number4
DOIs
StatePublished - Oct 16 2015

Keywords

  • breath acetone
  • controlled sampling
  • solid state sensors

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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  • Cite this

    Righettoni, M., Ragnoni, A., Güntner, A. T., Loccioni, C., Pratsinis, S. E., & Risby, T. H. (2015). Monitoring breath markers under controlled conditions. Journal of breath research, 9(4), [047101]. https://doi.org/10.1088/1752-7155/9/4/047101