@article{68402963575e4dfb8f6f9fdd069cfce3,
title = "Monetary reward processing in obese individuals with and without binge eating disorder",
abstract = "Background: An important step in obesity research involves identifying neurobiological underpinnings of nonfood reward processing unique to specific subgroups of obese individuals. Methods: Nineteen obese individuals seeking treatment for binge eating disorder (BED) were compared with 19 non-BED obese individuals (OB) and 19 lean control subjects (LC) while performing a monetary reward/loss task that parses anticipatory and outcome components during functional magnetic resonance imaging. Differences in regional activation were investigated in BED, OB, and LC groups during reward/loss prospect, anticipation, and notification. Results: Relative to the LC group, the OB group demonstrated increased ventral striatal and ventromedial prefrontal cortex activity during anticipatory phases. In contrast, the BED group relative to the OB group demonstrated diminished bilateral ventral striatal activity during anticipatory reward/loss processing. No differences were observed between the BED and LC groups in the ventral striatum. Conclusions: Heterogeneity exists among obese individuals with respect to the neural correlates of reward/loss processing. Neural differences in separable groups with obesity suggest that multiple, varying interventions might be important in optimizing prevention and treatment strategies for obesity.",
keywords = "Binge eating disorder, fMRI, inferior frontal gyrus, insula, obesity, reward, ventral striatum",
author = "Balodis, {Iris M.} and Hedy Kober and Worhunsky, {Patrick D.} and White, {Marney A.} and Stevens, {Michael C.} and Pearlson, {Godfrey D.} and Rajita Sinha and Grilo, {Carlos M.} and Potenza, {Marc N.}",
note = "Funding Information: Dr. Potenza has consulted for and advised Boehringer Ingelheim; consulted for and has financial interests in Somaxon; received research support from the NIH, Veterans Administration, Mohegan Sun Casino, the National Center for Responsible Gaming and its affiliated Institute for Research on Gambling Disorders, Forest Laboratories, Psyadon, Ortho-McNeil, Oy-Control/Biotie, and GlaxoSmithKline pharmaceuticals; participated in surveys, mailings, or telephone consultations related to drug addiction, impulse control disorders, or other health topics; consulted for law offices and the federal public defender{\textquoteright}s office in issues related to impulse control disorders; provides clinical care in the Connecticut Department of Mental Health and Addiction Services Problem Gambling Services Program; performed grant reviews for the NIH and other agencies; given academic lectures in grand rounds, continuing medical education events, and other clinical or scientific venues; and generated books or book chapters for publishers of mental health texts. All other authors report no biomedical financial interests or potential conflicts of interest. Funding Information: Support was provided by the following grants: National Institutes of Health (NIH) grants R01-DA019039, P20-DA027844, P50-AA012870, R01-DA020908, R01-AA016599, RL1-AA017539, K12-DA00167, R01 DK073542, PL1-DA024859, and 2K24 DK070052. We gratefully acknowledge Scott Bullock, Jessica Montoya, Naaila Panjwani, Monica Solorzano, Jocelyn Topf, Katie VanBuskirk, Rachel Barnes, and Robin Masheb for their help with the project. The contents of the manuscript are solely the responsibility of the authors and do not necessarily represent the official views of any of the funding agencies. ",
year = "2013",
month = may,
day = "1",
doi = "10.1016/j.biopsych.2013.01.014",
language = "English (US)",
volume = "73",
pages = "877--886",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "9",
}