Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators

Bradley J. Undem, Hui Sun

Research output: Contribution to journalArticle

Abstract

Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies.

Original languageEnglish (US)
Pages (from-to)57-68
Number of pages12
JournalPhysiology (Bethesda, Md.)
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2020

Fingerprint

Unmyelinated Nerve Fibers
Bronchoconstriction
Signs and Symptoms
Reflex
Respiration
Anti-Inflammatory Agents
Thorax
Lung
Therapeutics

Keywords

  • asthma
  • bronchoconstriction
  • C fibers
  • cough
  • vagus

ASJC Scopus subject areas

  • Physiology

Cite this

Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators. / Undem, Bradley J.; Sun, Hui.

In: Physiology (Bethesda, Md.), Vol. 35, No. 1, 01.01.2020, p. 57-68.

Research output: Contribution to journalArticle

@article{fae610dc9a0e4abcba5bee2711765922,
title = "Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators",
abstract = "Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies.",
keywords = "asthma, bronchoconstriction, C fibers, cough, vagus",
author = "Undem, {Bradley J.} and Hui Sun",
year = "2020",
month = "1",
day = "1",
doi = "10.1152/physiol.00014.2019",
language = "English (US)",
volume = "35",
pages = "57--68",
journal = "Physiology",
issn = "1548-9213",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators

AU - Undem, Bradley J.

AU - Sun, Hui

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies.

AB - Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies.

KW - asthma

KW - bronchoconstriction

KW - C fibers

KW - cough

KW - vagus

UR - http://www.scopus.com/inward/record.url?scp=85076035892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076035892&partnerID=8YFLogxK

U2 - 10.1152/physiol.00014.2019

DO - 10.1152/physiol.00014.2019

M3 - Article

C2 - 31799905

AN - SCOPUS:85076035892

VL - 35

SP - 57

EP - 68

JO - Physiology

JF - Physiology

SN - 1548-9213

IS - 1

ER -