Molecular/Ionic Basis of Vagal Bronchopulmonary C-Fiber Activation by Inflammatory Mediators

Research output: Contribution to journalArticle

Abstract

Stimulation of bronchopulmonary vagal afferent C fibers by inflammatory mediators can lead to coughing, chest tightness, and changes in breathing pattern, as well as reflex bronchoconstriction and secretions. These responses serve a defensive function in healthy lungs but likely contribute to many of the signs and symptoms of inflammatory airway diseases. A better understanding of the mechanisms underlying the activation of bronchopulmonary C-fiber terminals may lead to novel therapeutics that would work in an additive or synergic manner with existing anti-inflammatory strategies.

Original languageEnglish (US)
Pages (from-to)57-68
Number of pages12
JournalPhysiology (Bethesda, Md.)
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • asthma
  • bronchoconstriction
  • C fibers
  • cough
  • vagus

ASJC Scopus subject areas

  • Physiology

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