Molecular weight determination of underivatized oligodeoxyribonucleotides by positive‐ion matrix‐assisted ultraviolet laser‐desorption mass spectrometry

Bernhard Spengler, Ying Pan, Robert J. Cotter, Lou‐Sing ‐S Kan

Research output: Contribution to journalArticle

Abstract

A Wiley‐McLaren type time‐of‐flight mass spectrometer has been used for molecular weight measurements of several unprotected oligodeoxyribonucleotides using matrix‐assisted UV laser desorption. Approximately 10 to 100 pmol of sample was required for recording their positive‐ion mass spectra with a mass resolution in the range of 150 to 300 (Full width at half maximum) (FWHM). Little fragmentation was observed.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalRapid Communications in Mass Spectrometry
Volume4
Issue number4
DOIs
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Molecular weight determination of underivatized oligodeoxyribonucleotides by positive‐ion matrix‐assisted ultraviolet laser‐desorption mass spectrometry'. Together they form a unique fingerprint.

  • Cite this