Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation

Jon R. Lorsch, Thomas E. Dever

Research output: Contribution to journalShort survey


A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

Original languageEnglish (US)
Pages (from-to)21203-21207
Number of pages5
JournalJournal of Biological Chemistry
Issue number28
StatePublished - Jul 9 2010


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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