Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation

Jon R. Lorsch, Thomas E. Dever

Research output: Contribution to journalArticle

Abstract

A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

Original languageEnglish (US)
Pages (from-to)21203-21207
Number of pages5
JournalJournal of Biological Chemistry
Volume285
Issue number28
DOIs
StatePublished - Jul 9 2010

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Peptide Initiation Factors
Site selection
Initiator Codon
Ribosomes
Proteins
Molecular Models
Molecular Biology

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation. / Lorsch, Jon R.; Dever, Thomas E.

In: Journal of Biological Chemistry, Vol. 285, No. 28, 09.07.2010, p. 21203-21207.

Research output: Contribution to journalArticle

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