TY - JOUR
T1 - Molecular Updates in Prostate Cancer
AU - Netto, George J.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted.
AB - A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted.
KW - Carcinogenesis
KW - Genomic classification
KW - PCA3
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84951806530&partnerID=8YFLogxK
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U2 - 10.1016/j.path.2015.08.003
DO - 10.1016/j.path.2015.08.003
M3 - Review article
C2 - 26612215
AN - SCOPUS:84951806530
SN - 1875-9181
VL - 8
SP - 561
EP - 580
JO - Surgical Pathology Clinics
JF - Surgical Pathology Clinics
IS - 4
ER -