Molecular Updates in Prostate Cancer

George J. Netto

Research output: Contribution to journalReview article

Abstract

A wide array of molecular markers and genomic signatures, reviewed in this article, may soon be used as adjuncts to currently established screening strategies, prognostic parameters, and early detection markers. Markers of genetic susceptibility to PCA, recurrent epigenetic and genetic alterations, including ETS gene fusions, PTEN alterations, and urine-based early detection marker PCA3, are discussed. Impact of recent genome-wide assessment on our understanding of key pathways of PCA development and progression and their potential clinical implications are highlighted.

Original languageEnglish (US)
Pages (from-to)561-580
Number of pages20
JournalSurgical Pathology Clinics
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Carcinogenesis
  • Genomic classification
  • PCA3
  • Prostate cancer

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

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