Abstract
The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In this review, we summarize recent developments in the design of three broad classes of molecular tools for perturbing signal transduction, classified by their type of input signal: chemically induced, optically induced, and magnetically induced.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-142 |
| Number of pages | 8 |
| Journal | Current Opinion in Chemical Biology |
| Volume | 34 |
| DOIs | |
| State | Published - Oct 1 2016 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
Cite this
Molecular tools for acute spatiotemporal manipulation of signal transduction. / Ross, Brian; Mehta, Sohum; Zhang, Jin.
In: Current Opinion in Chemical Biology, Vol. 34, 01.10.2016, p. 135-142.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Molecular tools for acute spatiotemporal manipulation of signal transduction
AU - Ross, Brian
AU - Mehta, Sohum
AU - Zhang, Jin
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In this review, we summarize recent developments in the design of three broad classes of molecular tools for perturbing signal transduction, classified by their type of input signal: chemically induced, optically induced, and magnetically induced.
AB - The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In this review, we summarize recent developments in the design of three broad classes of molecular tools for perturbing signal transduction, classified by their type of input signal: chemically induced, optically induced, and magnetically induced.
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UR - http://www.scopus.com/inward/citedby.url?scp=84987971141&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2016.08.012
DO - 10.1016/j.cbpa.2016.08.012
M3 - Review article
C2 - 27639090
AN - SCOPUS:84987971141
VL - 34
SP - 135
EP - 142
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
ER -