Molecular tools for acute spatiotemporal manipulation of signal transduction

Brian Ross, Sohum Mehta, Jin Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In this review, we summarize recent developments in the design of three broad classes of molecular tools for perturbing signal transduction, classified by their type of input signal: chemically induced, optically induced, and magnetically induced.

Original languageEnglish (US)
Pages (from-to)135-142
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume34
DOIs
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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