Molecular Toggle Switch of Histone Demethylase LSD1

Jaehoon Shin; Guo li Ming; Hongjun Song

doi:10.1016/j.molcel.2015.03.007

Molecular Toggle Switch of Histone Demethylase LSD1

Jaehoon Shin, Guo li Ming, Hongjun Song

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In this issue of Molecular Cell, Laurent etal. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis. In this issue of Molecular Cell, Laurent etal. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.

Original language	English (US)
Pages (from-to)	949-950
Number of pages	2
Journal	Molecular Cell
Volume	57
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2015.03.007
State	Published - Mar 19 2015

ASJC Scopus subject areas

Molecular Biology
Cell Biology
Medicine(all)

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10.1016/j.molcel.2015.03.007

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abstract = "In this issue of Molecular Cell, Laurent etal. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis. In this issue of Molecular Cell, Laurent etal. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.",

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Molecular Toggle Switch of Histone Demethylase LSD1

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