Molecular Toggle Switch of Histone Demethylase LSD1

Jaehoon Shin, Guo li Ming, Hongjun Song

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Molecular Cell, Laurent etal. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis. In this issue of Molecular Cell, Laurent etal. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.

Original languageEnglish (US)
Pages (from-to)949-950
Number of pages2
JournalMolecular Cell
Volume57
Issue number6
DOIs
StatePublished - Mar 19 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Medicine(all)

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