@article{9ae7bac1860a47a3a11c8337e198875c,
title = "Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease during Treatment Reveals Changing Coinfection with Mixtures of Borrelia burgdorferi Genotypes",
abstract = "Borrelia burgdorferi is the etiological agent of Lyme disease. In the current study, we used direct-detection PCR and electrospray ionization mass spectrometry to monitor and genotype B. burgdorferi isolates from serially collected whole-blood specimens from patients clinically diagnosed with early Lyme disease before and during 21 days of antibiotic therapy. B. burgdorferi isolates were detected up to 3 weeks after the initiation of antibiotic treatment, with ratios of coinfecting B. burgdorferi genotypes changing over time.",
keywords = "Antibiotic, Borrelia burgdorferi, Genotype, Lyme disease, Time course",
author = "Mosel, {Michael R.} and Carolan, {Heather E.} and Rebman, {Alison W.} and Steven Castro and Christian Massire and Ecker, {David J.} and Soloski, {Mark J.} and Aucott, {John N.} and Eshoo, {Mark W.}",
note = "Funding Information: This work was supported by the Bay Area Lyme Foundation and the Steven and Alexandra Cohen Foundation. We thank Erica Mihm and Cheryl Novak for assistance with participant study visits. M.R.M., H.E.C., S.C., C.M., D.J.E., and M.W.E. were all employees of Ibis Biosciences, an Abbott Company, which developed the PCR/ESI-MS assays and instrumentation used in these studies; assays described are for research use only. A.W.R., M.J.S., and J.N.A. have no conflicts of interest to declare. Publisher Copyright: Copyright {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",
year = "2019",
doi = "10.1128/AAC.00237-19",
language = "English (US)",
volume = "63",
journal = "Antimicrobial agents and chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "7",
}