TY - JOUR
T1 - Molecular targeting of glioblastoma
T2 - Drug discovery and therapies
AU - Bai, Ren Yuan
AU - Staedtke, Verena
AU - Riggins, Gregory J.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/6
Y1 - 2011/6
N2 - Despite advances in treatment for glioblastoma multiforme (GBM), patient prognosis remains poor. Although there is growing evidence that molecular targeting could translate into better survival for GBM, current clinical data show limited impact on survival. Recent progress in GBM genomics implicate several activated pathways and numerous mutated genes. This molecular diversity can partially explain therapeutic resistance and several approaches have been postulated to target molecular changes. Furthermore, most drugs are unable to reach effective concentrations within the tumor owing to elevated intratumoral pressure, restrictive vasculature and other limiting factors. Here, we describe the preclinical and clinical developments in treatment strategies of GBM. We review the current clinical trials for GBM and discuss the challenges and future directions of targeted therapies.
AB - Despite advances in treatment for glioblastoma multiforme (GBM), patient prognosis remains poor. Although there is growing evidence that molecular targeting could translate into better survival for GBM, current clinical data show limited impact on survival. Recent progress in GBM genomics implicate several activated pathways and numerous mutated genes. This molecular diversity can partially explain therapeutic resistance and several approaches have been postulated to target molecular changes. Furthermore, most drugs are unable to reach effective concentrations within the tumor owing to elevated intratumoral pressure, restrictive vasculature and other limiting factors. Here, we describe the preclinical and clinical developments in treatment strategies of GBM. We review the current clinical trials for GBM and discuss the challenges and future directions of targeted therapies.
UR - http://www.scopus.com/inward/record.url?scp=79958766637&partnerID=8YFLogxK
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U2 - 10.1016/j.molmed.2011.01.011
DO - 10.1016/j.molmed.2011.01.011
M3 - Review article
C2 - 21411370
AN - SCOPUS:79958766637
SN - 1471-4914
VL - 17
SP - 301
EP - 312
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 6
ER -