TY - JOUR
T1 - Molecular sonography with targeted microbubbles
T2 - Current investigations and potential applications
AU - Hwang, Misun
AU - Lyshchik, Andrej
AU - Fleischer, Arthur C.
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Sonography using targeted microbubbles affords a variety of diagnostic and potentially therapeutic clinical applications. It provides a whole new world of functional information at the cellular and molecular level. This information can then be used to diagnose and possibly prevent diseases at early stages as well as devise therapeutic strategies at the molecular level. It is also useful in monitoring tumor response to therapy and devising treatment timing and plans based on the molecular state of an individual's health. Moreover, targeted microbubble-enhanced sonography has several advantages over other imaging modalities, including widespread availability, low cost, fast acquisition times, and lack of radiation risk. These traits are likely to advance it as one of the imaging methods of choice in future clinical trials examining the impact of molecular imaging on treatment outcome. This review describes the fundamental concepts of targeted microbubble-enhanced sonography as well as its potential clinical applications.
AB - Sonography using targeted microbubbles affords a variety of diagnostic and potentially therapeutic clinical applications. It provides a whole new world of functional information at the cellular and molecular level. This information can then be used to diagnose and possibly prevent diseases at early stages as well as devise therapeutic strategies at the molecular level. It is also useful in monitoring tumor response to therapy and devising treatment timing and plans based on the molecular state of an individual's health. Moreover, targeted microbubble-enhanced sonography has several advantages over other imaging modalities, including widespread availability, low cost, fast acquisition times, and lack of radiation risk. These traits are likely to advance it as one of the imaging methods of choice in future clinical trials examining the impact of molecular imaging on treatment outcome. This review describes the fundamental concepts of targeted microbubble-enhanced sonography as well as its potential clinical applications.
KW - Sonography
KW - Targeted microbubbles
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U2 - 10.1097/RUQ.0b013e3181df96de
DO - 10.1097/RUQ.0b013e3181df96de
M3 - Review article
C2 - 20498563
AN - SCOPUS:77952892389
VL - 26
SP - 75
EP - 82
JO - Ultrasound Quarterly
JF - Ultrasound Quarterly
SN - 0894-8771
IS - 2
ER -