Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study

Zurab Nadareishvili; Devon Kelley; Marie Luby; Alexis N. Simpkins; Richard Leigh; John K. Lynch; Amie W. Hsia; Richard T. Benson; Kory R. Johnson; John M. Hallenbeck; Lawrence L. Latour

doi:10.1002/acn3.757

Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study

Zurab Nadareishvili, Devon Kelley, Marie Luby, Alexis N. Simpkins, Richard Leigh, John K. Lynch, Amie W. Hsia, Richard T. Benson, Kory R. Johnson, John M. Hallenbeck, Lawrence L. Latour

Research output: Contribution to journal › Article › peer-review

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Abstract

We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion–diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion–diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score −2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.

Original language	English (US)
Pages (from-to)	817-820
Number of pages	4
Journal	Annals of Clinical and Translational Neurology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1002/acn3.757
State	Published - Apr 2019
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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title = "Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study",

abstract = "We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion–diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion–diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score −2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.",

author = "Zurab Nadareishvili and Devon Kelley and Marie Luby and Simpkins, {Alexis N.} and Richard Leigh and Lynch, {John K.} and Hsia, {Amie W.} and Benson, {Richard T.} and Johnson, {Kory R.} and Hallenbeck, {John M.} and Latour, {Lawrence L.}",

note = "Funding Information: Study was supported by the Intramural Research Program of the NINDS, National Institutes of Health (NIH). Publisher Copyright: {\textcopyright} 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.",

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doi = "10.1002/acn3.757",

language = "English (US)",

volume = "6",

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T1 - Molecular signature of penumbra in acute ischemic stroke

T2 - a pilot transcriptomics study

AU - Nadareishvili, Zurab

AU - Kelley, Devon

AU - Luby, Marie

AU - Simpkins, Alexis N.

AU - Leigh, Richard

AU - Lynch, John K.

AU - Hsia, Amie W.

AU - Benson, Richard T.

AU - Johnson, Kory R.

AU - Hallenbeck, John M.

AU - Latour, Lawrence L.

N1 - Funding Information: Study was supported by the Intramural Research Program of the NINDS, National Institutes of Health (NIH). Publisher Copyright: © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

PY - 2019/4

Y1 - 2019/4

N2 - We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion–diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion–diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score −2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.

AB - We aimed to characterize peripheral blood gene expression profile of penumbra defined as MRI perfusion–diffusion mismatch (PD MM) in peripheral blood of patients with acute ischemic stroke. We studied 23 patients. Perfusion–diffusion mismatch volume was observed to be associated and significantly correlated with the expression of 34 genes including those related to inflammation, SUMOylation, and coagulation; while lipopolysaccharide inhibition was identified to be a candidate upstream regulator of these processes (z-score −2.38, P = 0.04). Penumbral volume is correlated with a specific gene expression profile in the peripheral blood characterized by overlap of inflammatory and neuroprotective pathways that are regulated by lipopolysaccharide inhibition.

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JF - Annals of Clinical and Translational Neurology

IS - 4

ER -

Molecular signature of penumbra in acute ischemic stroke: a pilot transcriptomics study

Abstract

ASJC Scopus subject areas

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