Molecular signaling in pathogenesis of craniosynostosis: The role of fibroblast growth factor and transforming growth factor-β

Harvey Chim, Sunil Manjila, Alan Cohen, Arun K. Gosain

Research output: Contribution to journalArticle

Abstract

The interplay of signals between dura mater, suture mesenchyme, and brain is essential in determining the fate of cranial sutures and the pathogenesis of premature suture fusion leading to craniosynostosis. At the forefront of research into suture fusion is the role of fibroblast growth factor and transforming growth factor-β, which have been found to be critical in the cell-signaling cascade involved in aberrant suture fusion. In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-β in the etiopathogenesis of craniosynostosis.

Original languageEnglish (US)
Article numberE7
JournalNeurosurgical Focus
Volume31
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Craniosynostoses
Fibroblast Growth Factors
Transforming Growth Factors
Sutures
Cranial Sutures
Dura Mater
Mesoderm
Research
Brain

Keywords

  • Craniosynostosis
  • Fibroblast growth factor
  • Molecular signaling
  • Pathogenesis
  • Transforming growth factor-beta

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Molecular signaling in pathogenesis of craniosynostosis : The role of fibroblast growth factor and transforming growth factor-β. / Chim, Harvey; Manjila, Sunil; Cohen, Alan; Gosain, Arun K.

In: Neurosurgical Focus, Vol. 31, No. 2, E7, 08.2011.

Research output: Contribution to journalArticle

@article{a667d46e87c44d82aeee9f93e0a3bfb0,
title = "Molecular signaling in pathogenesis of craniosynostosis: The role of fibroblast growth factor and transforming growth factor-β",
abstract = "The interplay of signals between dura mater, suture mesenchyme, and brain is essential in determining the fate of cranial sutures and the pathogenesis of premature suture fusion leading to craniosynostosis. At the forefront of research into suture fusion is the role of fibroblast growth factor and transforming growth factor-β, which have been found to be critical in the cell-signaling cascade involved in aberrant suture fusion. In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-β in the etiopathogenesis of craniosynostosis.",
keywords = "Craniosynostosis, Fibroblast growth factor, Molecular signaling, Pathogenesis, Transforming growth factor-beta",
author = "Harvey Chim and Sunil Manjila and Alan Cohen and Gosain, {Arun K.}",
year = "2011",
month = "8",
doi = "10.3171/2011.5.FOCUS1197",
language = "English (US)",
volume = "31",
journal = "Neurosurgical Focus",
issn = "1092-0684",
publisher = "American Association of Neurological Surgeons",
number = "2",

}

TY - JOUR

T1 - Molecular signaling in pathogenesis of craniosynostosis

T2 - The role of fibroblast growth factor and transforming growth factor-β

AU - Chim, Harvey

AU - Manjila, Sunil

AU - Cohen, Alan

AU - Gosain, Arun K.

PY - 2011/8

Y1 - 2011/8

N2 - The interplay of signals between dura mater, suture mesenchyme, and brain is essential in determining the fate of cranial sutures and the pathogenesis of premature suture fusion leading to craniosynostosis. At the forefront of research into suture fusion is the role of fibroblast growth factor and transforming growth factor-β, which have been found to be critical in the cell-signaling cascade involved in aberrant suture fusion. In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-β in the etiopathogenesis of craniosynostosis.

AB - The interplay of signals between dura mater, suture mesenchyme, and brain is essential in determining the fate of cranial sutures and the pathogenesis of premature suture fusion leading to craniosynostosis. At the forefront of research into suture fusion is the role of fibroblast growth factor and transforming growth factor-β, which have been found to be critical in the cell-signaling cascade involved in aberrant suture fusion. In this review, the authors discuss recent and ongoing research into the role of fibroblast growth factor and transforming growth factor-β in the etiopathogenesis of craniosynostosis.

KW - Craniosynostosis

KW - Fibroblast growth factor

KW - Molecular signaling

KW - Pathogenesis

KW - Transforming growth factor-beta

UR - http://www.scopus.com/inward/record.url?scp=80052203175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052203175&partnerID=8YFLogxK

U2 - 10.3171/2011.5.FOCUS1197

DO - 10.3171/2011.5.FOCUS1197

M3 - Article

C2 - 21806346

AN - SCOPUS:80052203175

VL - 31

JO - Neurosurgical Focus

JF - Neurosurgical Focus

SN - 1092-0684

IS - 2

M1 - E7

ER -