Molecular signaling and targets from itch: Lessons for cough

Pamela Colleen LaVinka, Xinzhong Dong

Research output: Contribution to journalArticle

Abstract

Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

Original languageEnglish (US)
Article number8
JournalCough
Volume9
Issue number1
DOIs
StatePublished - Mar 6 2013

Fingerprint

Cough
Irritants
Mast Cells
Inflammation
Neuropeptides
Reflex
Anatomy
Skin

Keywords

  • A-fibers
  • Airway
  • C-fibers
  • Cough
  • GPCRs
  • Inflammation
  • Itch
  • Mast cells
  • Skin
  • TRPs

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pulmonary and Respiratory Medicine

Cite this

Molecular signaling and targets from itch : Lessons for cough. / LaVinka, Pamela Colleen; Dong, Xinzhong.

In: Cough, Vol. 9, No. 1, 8, 06.03.2013.

Research output: Contribution to journalArticle

LaVinka, Pamela Colleen ; Dong, Xinzhong. / Molecular signaling and targets from itch : Lessons for cough. In: Cough. 2013 ; Vol. 9, No. 1.
@article{44ed9812ed7346d580a3241ef19c8a02,
title = "Molecular signaling and targets from itch: Lessons for cough",
abstract = "Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.",
keywords = "A-fibers, Airway, C-fibers, Cough, GPCRs, Inflammation, Itch, Mast cells, Skin, TRPs",
author = "LaVinka, {Pamela Colleen} and Xinzhong Dong",
year = "2013",
month = "3",
day = "6",
doi = "10.1186/1745-9974-9-8",
language = "English (US)",
volume = "9",
journal = "Cough",
issn = "1745-9974",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Molecular signaling and targets from itch

T2 - Lessons for cough

AU - LaVinka, Pamela Colleen

AU - Dong, Xinzhong

PY - 2013/3/6

Y1 - 2013/3/6

N2 - Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

AB - Itch is described as an unpleasant sensation that elicits the desire to scratch, which results in the removal of the irritant from the skin. The cough reflex also results from irritation, with the purpose of removing said irritant from the airway. Could cough then be similar to itch? Anatomically, both pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. Both cough and itch also involve mast cells and their mediators, which are released upon degranulation. This common inflammation and interaction with mast cells are involved in the development of chronic conditions of itch and cough. In this review, we examine the anatomy and molecular mechanisms of itch and compare them to known mechanisms for cough. Highlighting the common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

KW - A-fibers

KW - Airway

KW - C-fibers

KW - Cough

KW - GPCRs

KW - Inflammation

KW - Itch

KW - Mast cells

KW - Skin

KW - TRPs

UR - http://www.scopus.com/inward/record.url?scp=84874519786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874519786&partnerID=8YFLogxK

U2 - 10.1186/1745-9974-9-8

DO - 10.1186/1745-9974-9-8

M3 - Article

C2 - 23497684

AN - SCOPUS:84874519786

VL - 9

JO - Cough

JF - Cough

SN - 1745-9974

IS - 1

M1 - 8

ER -