Molecular rhythms in the pineal gland

Xiaodong Li, Jimo Borjigin, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Recent findings have clarified the mechanisms regulating the night- and pineal-specific transcription of serotonin N-acetyltransferase, the rate-limiting enzyme in melatonin formation. Norepinephrine acting via β-adrenoceptors and cAMP at night, stimulates the cAMP response element binding protein, which turns on the transcription of N-acetyltransferase and inducible cAMP early repressor, the major inhibitor of N-acetyltransferase transcription. The tissue-specific gene expression within the pineal gland and retina derives, in part, from a pineal/retina-specific transcription factor, cone-rod homeobox protein, which binds to a pineal regulatory element. This regulatory element is present in promoters of pineal-selective enzymes, such as N-acetyltransferase, hydroxyindole-O-methyl transferase, and pineal night-specific ATPase.

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalCurrent Opinion in Neurobiology
Volume8
Issue number5
DOIs
StatePublished - Oct 1998

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Acetyltransferases
Pineal Gland
Retina
Arylalkylamine N-Acetyltransferase
Cyclic AMP Response Element-Binding Protein
Melatonin
Enzymes
Transferases
Adrenergic Receptors
Norepinephrine
Transcription Factors
Gene Expression

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular rhythms in the pineal gland. / Li, Xiaodong; Borjigin, Jimo; Snyder, Solomon H.

In: Current Opinion in Neurobiology, Vol. 8, No. 5, 10.1998, p. 648-651.

Research output: Contribution to journalArticle

Li, Xiaodong ; Borjigin, Jimo ; Snyder, Solomon H. / Molecular rhythms in the pineal gland. In: Current Opinion in Neurobiology. 1998 ; Vol. 8, No. 5. pp. 648-651.
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