Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis

Irving Nachamkin, J�rgen Engberg, Michaela Gutacker, Richard J. Meinersman, Chun Yan Li, Patricia Arzate, Erin Teeple, Vivian Fussing, Tony W. Ho, Arthur K. Asbury, John W. Griffin, Guy M. McKhann, Jean Claude Piffaretti

Research output: Contribution to journalArticlepeer-review

Abstract

Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalJournal of Infectious Diseases
Volume184
Issue number2
DOIs
StatePublished - Jul 15 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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