TY - JOUR
T1 - Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis
AU - Nachamkin, Irving
AU - Engberg, J�rgen
AU - Gutacker, Michaela
AU - Meinersman, Richard J.
AU - Li, Chun Yan
AU - Arzate, Patricia
AU - Teeple, Erin
AU - Fussing, Vivian
AU - Ho, Tony W.
AU - Asbury, Arthur K.
AU - Griffin, John W.
AU - McKhann, Guy M.
AU - Piffaretti, Jean Claude
N1 - Funding Information:
Financial support: National Institutes of Health (NS-31528 to G.M.M., J.W.G., and I.N.); Swiss National Science Foundation (31-45914,95 to J.-C.P.).
PY - 2001/7/15
Y1 - 2001/7/15
N2 - Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.
AB - Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.
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U2 - 10.1086/322008
DO - 10.1086/322008
M3 - Article
C2 - 11400077
AN - SCOPUS:0035879709
SN - 0022-1899
VL - 184
SP - 221
EP - 226
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -