Molecular pharmacology of isoprostanes in vascular smooth muscle

Aïda Habib, Kamal F. Badr

Research output: Contribution to journalArticle

Abstract

Isoprostanes are marker of lipid peroxidation and are produced after free-radical attack of membrane lipids. In addition, they are biologically active and are essentially vaso- and broncho-constrictor. Their smooth muscle constrictor actions are closely linked to the activation of the thromboxane A2 receptor, but also involve a distinct receptor not yet identified. The response of vascular smooth muscle to isoprostanes is subclass-specific (F-series versus E-series isoprostanes) and cell- and species-related. In this review, we will address the vascular actions of isoprostanes and their possible role in vascular physiology and pathophysiology.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalChemistry and Physics of Lipids
Volume128
Issue number1-2
DOIs
StatePublished - Mar 2004
Externally publishedYes

Keywords

  • Constriction
  • Isoprostanes
  • Platelet
  • Signaling
  • Vascular cells

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Fingerprint Dive into the research topics of 'Molecular pharmacology of isoprostanes in vascular smooth muscle'. Together they form a unique fingerprint.

  • Cite this