Molecular pathways in pancreatic carcinogenesis

Anne M. MacGregor-Das, Christine A. Iacobuzio-Donahue

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic cancer is a genetic disease. Pancreatic cancers develop from one of three precursor lesions, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and mucinous cystic neoplasms (MCNs), and each arises in association with distinct genetic alterations. These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors. J. Surg. Oncol. 2013;107:8-14.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalJournal of Surgical Oncology
Volume107
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • GNAS
  • RNF43
  • cystic neoplasm
  • pancreatic cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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