Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development

Kristen Johnson, Karen L. Reddy, Harinder Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specificstages of B-celldevelopment. We review this emergent framework and discussnew experimental approaches that will be needed to explore the underlying molecular mechanisms.

Original languageEnglish (US)
Title of host publicationV(D)J Recombination
EditorsPierre Ferrier
Pages133-147
Number of pages15
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume650
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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