@inbook{3d80f9101f6b4b008c62c7c7328041dc,
title = "Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development",
abstract = "The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specificstages of B-celldevelopment. We review this emergent framework and discussnew experimental approaches that will be needed to explore the underlying molecular mechanisms.",
author = "Kristen Johnson and Reddy, {Karen L.} and Harinder Singh",
year = "2009",
month = dec,
day = "1",
doi = "10.1007/978-1-4419-0296-2_11",
language = "English (US)",
isbn = "9781441902955",
series = "Advances in Experimental Medicine and Biology",
pages = "133--147",
editor = "Pierre Ferrier",
booktitle = "V(D)J Recombination",
}