Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development

Kristen Johnson, Karen L Reddy, Harinder Singh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specificstages of B-celldevelopment. We review this emergent framework and discussnew experimental approaches that will be needed to explore the underlying molecular mechanisms.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages133-147
Number of pages15
Volume650
DOIs
StatePublished - 2009
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume650
ISSN (Print)00652598

Fingerprint

Immunoglobulin Genes
Lymphocytes
Genetic Recombination
Immunoglobulins
B-Lymphocytes
Genes
Chromatin
Transcription Factors
Antigen Receptors
Cells
Gene Regulatory Networks

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Johnson, K., Reddy, K. L., & Singh, H. (2009). Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development. In Advances in Experimental Medicine and Biology (Vol. 650, pp. 133-147). (Advances in Experimental Medicine and Biology; Vol. 650). https://doi.org/10.1007/978-1-4419-0296-2_11

Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development. / Johnson, Kristen; Reddy, Karen L; Singh, Harinder.

Advances in Experimental Medicine and Biology. Vol. 650 2009. p. 133-147 (Advances in Experimental Medicine and Biology; Vol. 650).

Research output: Chapter in Book/Report/Conference proceedingChapter

Johnson, K, Reddy, KL & Singh, H 2009, Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development. in Advances in Experimental Medicine and Biology. vol. 650, Advances in Experimental Medicine and Biology, vol. 650, pp. 133-147. https://doi.org/10.1007/978-1-4419-0296-2_11
Johnson K, Reddy KL, Singh H. Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development. In Advances in Experimental Medicine and Biology. Vol. 650. 2009. p. 133-147. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-0296-2_11
Johnson, Kristen ; Reddy, Karen L ; Singh, Harinder. / Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development. Advances in Experimental Medicine and Biology. Vol. 650 2009. pp. 133-147 (Advances in Experimental Medicine and Biology).
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