Abstract
The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specificstages of B-celldevelopment. We review this emergent framework and discussnew experimental approaches that will be needed to explore the underlying molecular mechanisms.
| Original language | English (US) |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Pages | 133-147 |
| Number of pages | 15 |
| Volume | 650 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 650 |
| ISSN (Print) | 00652598 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development. / Johnson, Kristen; Reddy, Karen L; Singh, Harinder.
Advances in Experimental Medicine and Biology. Vol. 650 2009. p. 133-147 (Advances in Experimental Medicine and Biology; Vol. 650).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-Lymphocyte development
AU - Johnson, Kristen
AU - Reddy, Karen L
AU - Singh, Harinder
PY - 2009
Y1 - 2009
N2 - The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specificstages of B-celldevelopment. We review this emergent framework and discussnew experimental approaches that will be needed to explore the underlying molecular mechanisms.
AB - The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the ordered recombination of immunoglobulin (Ig) genes. Recombination of antigen-receptor loci is regulated both by the developmentally controlled expression of the Rag1 and Rag2 genes and the accessibility of particular loci and their gene segments to recombination. A new framework has emerged that invokes nuclear compartmentalization, large-scale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specificstages of B-celldevelopment. We review this emergent framework and discussnew experimental approaches that will be needed to explore the underlying molecular mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=70349571324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349571324&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-0296-2_11
DO - 10.1007/978-1-4419-0296-2_11
M3 - Chapter
C2 - 19731807
AN - SCOPUS:70349571324
SN - 9781441902955
VL - 650
T3 - Advances in Experimental Medicine and Biology
SP - 133
EP - 147
BT - Advances in Experimental Medicine and Biology
ER -