Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities

Levent Trabzonlu, Ibrahim Kulac, Qizhi Zheng, Jessica L. Hicks, Michael C. Haffner, William G Nelson, Karen Sfanos, Onur Ertunc, Tamara Lotan, Christopher M Heaphy, Alan Keith Meeker, S Yegnasubramanian, Angelo Michael Demarzo

Research output: Contribution to journalReview article

Abstract

A better understanding of the early stages of prostate cancer initiation, potentially arising from precursor lesions, may fuel development of powerful approaches for prostate cancer prevention or interception. The best-known candidate for such a precursor lesion has been referred to as high-grade prostatic intraepithelial neoplasia (HGPIN). Although there is significant evidence supporting the notion that such HGPIN lesions can give rise to invasive adenocarcinomas of the prostate, there are also numerous complicating considerations and evidence that cloud the picture in many instances. Notably, recent evidence has suggested that some fraction of such lesions that are morphologically consistent with HGPIN may actually be invasive carcinomas masquerading as HGPIN-a state that we term "postinvasive intraepithelial carcinoma" (PIC). Although the prevalence of such PIC lesions is not fully understood, this and other factors can confound the potential of identifying prostate precursors that can be targeted for disease prevention, interception, or treatment. Here, we review our current understanding of the morphological and molecular pathological features of prostate cancer precursor lesions.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Medicine
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2019

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Prostatic Intraepithelial Neoplasia
Molecular Pathology
Pathology
Prostatic Neoplasms
Carcinoma in Situ
Prostate
Adenocarcinoma
Carcinoma

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia : Challenges and Opportunities. / Trabzonlu, Levent; Kulac, Ibrahim; Zheng, Qizhi; Hicks, Jessica L.; Haffner, Michael C.; Nelson, William G; Sfanos, Karen; Ertunc, Onur; Lotan, Tamara; Heaphy, Christopher M; Meeker, Alan Keith; Yegnasubramanian, S; Demarzo, Angelo Michael.

In: Cold Spring Harbor Perspectives in Medicine, Vol. 9, No. 4, 01.04.2019.

Research output: Contribution to journalReview article

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