Molecular pathogenesis of pancreatic cancer

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143 Scopus citations


Pancreatic cancer is fundamentally a disease of inherited and acquired mutations in cancer-related genes. The genes targeted in pancreatic cancer include tumor-suppressor genes (p16/CDKN2A, TP53 and SMAD4), oncogenes (KRAS, BRAF, AKT2, MYB, and AIB1), and genome-maintenance genes (MLH1, MSH2, BRAC2 and other Fanconi anemia genes). An understanding of the cancer-related genes that are altered in pancreatic cancer has a number of clinical applications including genetic counseling for individuals with a family history of cancer, early detection of pancreatic neoplasia, and mechanism-based therapies for patients with advanced disease. This chapter will provide an overview of the molecular pathogenesis of pancreatic cancer with emphasis on clinical applications.

Original languageEnglish (US)
Pages (from-to)211-226
Number of pages16
JournalBest Practice and Research: Clinical Gastroenterology
Issue number2
StatePublished - Apr 2006


  • Familial aggregation
  • Oncogene
  • Pancreatic cancer
  • Screening
  • Treatment
  • Tumor-suppressor gene

ASJC Scopus subject areas

  • Gastroenterology


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