Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender

Jeffrey Patterson-Fortin, Alison R Moliterno

Research output: Contribution to journalArticlepeer-review

Abstract

The myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) display distinct clinical and pathologic features but are characterized by mutations in JAK2, MPL, and CALR leading to activation of the JAK-STAT pathway. This review addresses the pathogenesis and mechanisms of these mutant alleles and the unique interactions of both of age and gender.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCurrent Hematologic Malignancy Reports
DOIs
StateAccepted/In press - Sep 25 2017

Keywords

  • Aging
  • JAK2
  • Myeloproliferative neoplasms
  • Pathogenesis
  • Sex differences

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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