Molecular neurodevelopment: An in vivo 31P-1H MRSI study

Gerald Goldstein; Kanagasabai Panchalingam; Richard J. Mcclure; Jeffrey A. Stanley; Vince D. Calhoun; Godfrey D. Pearlson; Jay W. Pettegrew

doi:10.1017/S1355617709990233

Molecular neurodevelopment: An in vivo ³¹P-¹H MRSI study

Gerald Goldstein, Kanagasabai Panchalingam, Richard J. Mcclure, Jeffrey A. Stanley, Vince D. Calhoun, Godfrey D. Pearlson, Jay W. Pettegrew

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. ³¹P-¹H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6-18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders.

Original language	English (US)
Pages (from-to)	671-683
Number of pages	13
Journal	Journal of the International Neuropsychological Society
Volume	15
Issue number	5
DOIs	https://doi.org/10.1017/S1355617709990233
State	Published - 2009
Externally published	Yes

Keywords

Adolescent development
Brain
Child development
Cognition
Magnetic resonance spectroscopy
Phosphocreatine
Phospholipid metabolism
Synapses

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Clinical Neurology
Psychiatry and Mental health

Access to Document

10.1017/S1355617709990233

Cite this

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title = "Molecular neurodevelopment: An in vivo 31P-1H MRSI study",

abstract = "Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6-18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders.",

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author = "Gerald Goldstein and Kanagasabai Panchalingam and Mcclure, {Richard J.} and Stanley, {Jeffrey A.} and Calhoun, {Vince D.} and Pearlson, {Godfrey D.} and Pettegrew, {Jay W.}",

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AU - Goldstein, Gerald

AU - Panchalingam, Kanagasabai

AU - Mcclure, Richard J.

AU - Stanley, Jeffrey A.

AU - Calhoun, Vince D.

AU - Pearlson, Godfrey D.

AU - Pettegrew, Jay W.

PY - 2009

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AB - Synaptic development and elimination are normal neurodevelopmental processes, which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging (MRSI) and structural magnetic resonance imaging (MRI) exams were conducted on 105 healthy children ages 6-18 years old to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and percent gray matter volume were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders.

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KW - Brain

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KW - Phospholipid metabolism

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