Molecular networks underlying myofibroblast fate and fibrosis

April Stempien-Otero, Deok Ho Kim, Jennifer Davis

Research output: Contribution to journalReview articlepeer-review

Abstract

Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the primary effectors of the heart's fibrotic response. This review is focused on defining myofibroblast physiology, its progenitor cell populations, and the core signaling network that orchestrates myofibroblast differentiation as a way of understanding the basic determinants of fibrotic disease in the heart and other tissues.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume97
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Keywords

  • Actin cytoskeleton
  • Differentiation
  • Fibrosis
  • Mitogen activated protein kinases
  • Myofibroblast
  • RNA binding proteins
  • TGFβ
  • TRP channels

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Molecular networks underlying myofibroblast fate and fibrosis'. Together they form a unique fingerprint.

Cite this