Molecular model of an alternative splice variant of human IL-4, IL- 4δ2, a naturally occurring inhibitor of IL-4-stimulated T cell proliferation

Vladimir P. Zav'yalov, Alexander I. Denesyuk, Barbara White, Vladimir V. Yurovsky, Sergei P. Atamas, Timo Korpela

Research output: Contribution to journalArticlepeer-review

Abstract

The molecular model of IL-4δ2, a naturally occurring splice variant of human IL-4 with exons 1, 3, and 4 in an open reading frame, is described. The second exon codes the main part of the long loop AB connected the helices A and B in parallel superposition. Therefore the hydrophobic core and the native fold of the rest part of IL-4δ2 molecule could be preserved without any significant changes only in the case of revolution of the helix A relative to other helices. In the result, the dominated a left-handed four- helix bundle structure of IL-4 with an up-up-down-down structural pattern is transformed to the IL-4δ2 structure with a down-up-down-down structural pattern.

Original languageEnglish (US)
Pages (from-to)149-152
Number of pages4
JournalImmunology Letters
Volume58
Issue number3
DOIs
StatePublished - Aug 1997
Externally publishedYes

Keywords

  • Inhibitory variant
  • Interleukin-4
  • Molecular model

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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