TY - JOUR
T1 - Molecular model of an alternative splice variant of human IL-4, IL- 4δ2, a naturally occurring inhibitor of IL-4-stimulated T cell proliferation
AU - Zav'yalov, Vladimir P.
AU - Denesyuk, Alexander I.
AU - White, Barbara
AU - Yurovsky, Vladimir V.
AU - Atamas, Sergei P.
AU - Korpela, Timo
PY - 1997/8
Y1 - 1997/8
N2 - The molecular model of IL-4δ2, a naturally occurring splice variant of human IL-4 with exons 1, 3, and 4 in an open reading frame, is described. The second exon codes the main part of the long loop AB connected the helices A and B in parallel superposition. Therefore the hydrophobic core and the native fold of the rest part of IL-4δ2 molecule could be preserved without any significant changes only in the case of revolution of the helix A relative to other helices. In the result, the dominated a left-handed four- helix bundle structure of IL-4 with an up-up-down-down structural pattern is transformed to the IL-4δ2 structure with a down-up-down-down structural pattern.
AB - The molecular model of IL-4δ2, a naturally occurring splice variant of human IL-4 with exons 1, 3, and 4 in an open reading frame, is described. The second exon codes the main part of the long loop AB connected the helices A and B in parallel superposition. Therefore the hydrophobic core and the native fold of the rest part of IL-4δ2 molecule could be preserved without any significant changes only in the case of revolution of the helix A relative to other helices. In the result, the dominated a left-handed four- helix bundle structure of IL-4 with an up-up-down-down structural pattern is transformed to the IL-4δ2 structure with a down-up-down-down structural pattern.
KW - Inhibitory variant
KW - Interleukin-4
KW - Molecular model
UR - http://www.scopus.com/inward/record.url?scp=0030763362&partnerID=8YFLogxK
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U2 - 10.1016/S0165-2478(97)00083-7
DO - 10.1016/S0165-2478(97)00083-7
M3 - Article
C2 - 9293395
AN - SCOPUS:0030763362
SN - 0165-2478
VL - 58
SP - 149
EP - 152
JO - Immunology Letters
JF - Immunology Letters
IS - 3
ER -