Molecular mimicry: A critical look at exemplary instances in human diseases

N. R. Rose; I. R. Mackay

doi:10.1007/PL00000716

Molecular mimicry: A critical look at exemplary instances in human diseases

N. R. Rose, I. R. Mackay

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

Molecular mimicry, the concept that antigenic determinants of microorganisms resemble antigenic determinants of the host, is frequently cited as a plausible mechanism to account for the association of infection and autoimmune disease. Based on analogous sequences of amino acids or on cross-reactions of monoclonal antibodies, numerous examples of such mimicry have been reported. There are, however, no clear examples of a human disease caused by molecular mimicry.

Original language	English (US)
Pages (from-to)	542-551
Number of pages	10
Journal	Cellular and Molecular Life Sciences
Volume	57
Issue number	4
DOIs	https://doi.org/10.1007/PL00000716
State	Published - 2000
Externally published	Yes

Keywords

Ankylosing spondylitis
Autoimmunity
Lyme disease
Molecular mimicry
Multiple sclerosis
Myocarditis
Rheumatoid arthritis
Type 1 diabetes

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/PL00000716

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AB - Molecular mimicry, the concept that antigenic determinants of microorganisms resemble antigenic determinants of the host, is frequently cited as a plausible mechanism to account for the association of infection and autoimmune disease. Based on analogous sequences of amino acids or on cross-reactions of monoclonal antibodies, numerous examples of such mimicry have been reported. There are, however, no clear examples of a human disease caused by molecular mimicry.

KW - Ankylosing spondylitis

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KW - Molecular mimicry

KW - Multiple sclerosis

KW - Myocarditis

KW - Rheumatoid arthritis

KW - Type 1 diabetes

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Molecular mimicry: A critical look at exemplary instances in human diseases

Abstract

Keywords

ASJC Scopus subject areas

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