Molecular mimicry: A critical look at exemplary instances in human diseases

N. R. Rose, I. R. Mackay

Research output: Contribution to journalReview articlepeer-review

Abstract

Molecular mimicry, the concept that antigenic determinants of microorganisms resemble antigenic determinants of the host, is frequently cited as a plausible mechanism to account for the association of infection and autoimmune disease. Based on analogous sequences of amino acids or on cross-reactions of monoclonal antibodies, numerous examples of such mimicry have been reported. There are, however, no clear examples of a human disease caused by molecular mimicry.

Original languageEnglish (US)
Pages (from-to)542-551
Number of pages10
JournalCellular and Molecular Life Sciences
Volume57
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Ankylosing spondylitis
  • Autoimmunity
  • Lyme disease
  • Molecular mimicry
  • Multiple sclerosis
  • Myocarditis
  • Rheumatoid arthritis
  • Type 1 diabetes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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