Molecular microbiology: New dimensions for cutaneous biology and wound healing

Research output: Contribution to journalArticle

Abstract

The role of bacteria in the pathogenesis of chronic, nonhealing wounds is unclear. All wounds are colonized with bacteria, but differentiating colonizers from invading organisms is difficult, if not impossible, at the present time. Furthermore, robust new molecular genomic techniques have shown that only 1% of bacteria can be grown in culture; anaerobes are especially difficult to identify using standard culture methods. Recent studies utilizing microbial genomic methods have demonstrated that chronic wounds are host to a wide range of microorganisms. New techniques also show that microorganisms are capable of forming highly organized biofilms within the wound that differ dramatically in gene expression and phenotype from bacteria that are typically seen in planktonic conditions. The aim of this review is to present a concise description of infectious agents as defined by new molecular techniques and to summarize what is known about the microbiology of chronic wounds in order to relate them to the pathophysiology and therapy of chronic wounds.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalJournal of Investigative Dermatology
Volume130
Issue number1
DOIs
StatePublished - Jan 2010

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Microbiology
Wound Healing
Bacteria
Skin
Wounds and Injuries
Microorganisms
Biofilms
Gene expression
Phenotype
Gene Expression

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Molecular microbiology : New dimensions for cutaneous biology and wound healing. / Martin, Jo M.; Zenilman, Jonathan Mark; Lazarus, Gerald Sylvan.

In: Journal of Investigative Dermatology, Vol. 130, No. 1, 01.2010, p. 38-48.

Research output: Contribution to journalArticle

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