Molecular methods in the diagnosis and management of chronic hepatitis B

Perumal Vivekanandan, Om Vir Singh

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic hepatitis B (CHB) infection remains a major global problem but the recent advances in molecular methods have revolutionized the diagnosis and management of CHB. Hepatitis B virus (HBV) DNA quantitation is the most useful molecular marker for the diagnosis and management of CHB. There is increasing evidence that the clinical outcome and efficacy of antiviral therapy for CHB could vary with the infecting HBV genotype, core promoter and precore mutations. Early identification of drug resistance is imperative in the management of CHB. The molecular methods for HBV DNA quantitation, HBV genotyping, the identification of mutants, genotypic and phenotypic methods for monitoring drug resistance and their utility and limitations for use in the diagnosis and monitoring of CHB are discussed in this article.

Original languageEnglish (US)
Pages (from-to)921-935
Number of pages15
JournalExpert Review of Molecular Diagnostics
Volume10
Issue number7
DOIs
StatePublished - Jul 1 2010

Keywords

  • HBV DNA quantitation
  • HBV genotyping
  • core promoter mutants
  • drug resistance
  • hepatitis B virus
  • molecular methods
  • occult HBV
  • precore mutants

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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