Molecular messengers of olfaction

Gabriele V. Ronnett; Solomon H. Snyder

doi:10.1016/0166-2236(92)90104-G

Molecular messengers of olfaction

Gabriele V. Ronnett, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Review article › peer-review

88 Scopus citations

Abstract

Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca²⁺-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca²⁺ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

Original language	English (US)
Pages (from-to)	508-513
Number of pages	6
Journal	Trends in neurosciences
Volume	15
Issue number	12
DOIs	https://doi.org/10.1016/0166-2236(92)90104-G
State	Published - Dec 1992

ASJC Scopus subject areas

General Neuroscience

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10.1016/0166-2236(92)90104-G

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title = "Molecular messengers of olfaction",

abstract = "Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.",

author = "Ronnett, {Gabriele V.} and Snyder, {Solomon H.}",

note = "Funding Information: Supportedb y USPHS grants DA-OO266t o S.H.S.,N 5-01231 to G. V.R.,a McKnight ScholarsA warda nd JohnsHopkins ClinicianS cientist Awardt o G. V.R., ResearchS cientist A wardD A-00074 to S.H.S.,a grant of IntemationalF lavors and Fragrances,a nda grant from the Keck Foundation. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1992",

month = dec,

doi = "10.1016/0166-2236(92)90104-G",

language = "English (US)",

volume = "15",

pages = "508--513",

journal = "Trends in neurosciences",

issn = "0166-2236",

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T1 - Molecular messengers of olfaction

AU - Ronnett, Gabriele V.

AU - Snyder, Solomon H.

N1 - Funding Information: Supportedb y USPHS grants DA-OO266t o S.H.S.,N 5-01231 to G. V.R.,a McKnight ScholarsA warda nd JohnsHopkins ClinicianS cientist Awardt o G. V.R., ResearchS cientist A wardD A-00074 to S.H.S.,a grant of IntemationalF lavors and Fragrances,a nda grant from the Keck Foundation. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1992/12

Y1 - 1992/12

N2 - Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

AB - Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

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U2 - 10.1016/0166-2236(92)90104-G

DO - 10.1016/0166-2236(92)90104-G

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AN - SCOPUS:0026492648

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VL - 15

SP - 508

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JO - Trends in neurosciences

JF - Trends in neurosciences

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Molecular messengers of olfaction

Abstract

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