Molecular messengers of olfaction

Gabriele V. Ronnett, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

Original languageEnglish (US)
Pages (from-to)508-513
Number of pages6
JournalTrends in Neurosciences
Volume15
Issue number12
DOIs
StatePublished - 1992

Fingerprint

Odorant Receptors
Smell
Cilia
Type 1 Cyclic Nucleotide Phosphodiesterases
Olfactory Receptor Neurons
Olfactory Mucosa
Molecular Cloning
Second Messenger Systems
Phosphatidylinositols
GTP-Binding Proteins
Adenylyl Cyclases
Signal Transduction
Odorants

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular messengers of olfaction. / Ronnett, Gabriele V.; Snyder, Solomon H.

In: Trends in Neurosciences, Vol. 15, No. 12, 1992, p. 508-513.

Research output: Contribution to journalArticle

Ronnett, Gabriele V. ; Snyder, Solomon H. / Molecular messengers of olfaction. In: Trends in Neurosciences. 1992 ; Vol. 15, No. 12. pp. 508-513.
@article{524a7a46684442e5ac7c734011731b8e,
title = "Molecular messengers of olfaction",
abstract = "Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.",
author = "Ronnett, {Gabriele V.} and Snyder, {Solomon H}",
year = "1992",
doi = "10.1016/0166-2236(92)90104-G",
language = "English (US)",
volume = "15",
pages = "508--513",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - Molecular messengers of olfaction

AU - Ronnett, Gabriele V.

AU - Snyder, Solomon H

PY - 1992

Y1 - 1992

N2 - Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

AB - Our knowledge of olfactory signal transduction has been greatly clarified by several recent advances. Molecular cloning has revealed a large family of putative odorant receptors localized to olfactory epithelium that display a seven-transmembrane-domain motif suggesting an association with G proteins. Very potent and rapid enhancement of both adenylyl cyclase and phosphoinositide turnover has been demonstrated in response to odorants both in isolated olfactory cilia and primary olfactory receptor neuronal cultures. Ca2+-calmodulin-dependent phosphodiesterase has been localized to olfactory cilia. A key role for Ca2+ is evident from many investigations. More recently, odorants have also been shown to affect the levels of cGMP in olfactory receptor neurons. The involvement of multiple second messengers may provide mechanisms for both fine-tuning and desensitization of olfaction.

UR - http://www.scopus.com/inward/record.url?scp=0026492648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026492648&partnerID=8YFLogxK

U2 - 10.1016/0166-2236(92)90104-G

DO - 10.1016/0166-2236(92)90104-G

M3 - Article

C2 - 1282752

AN - SCOPUS:0026492648

VL - 15

SP - 508

EP - 513

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 12

ER -