Molecular Mechanisms of Polarized Protein Trafficking in Epithelial Cells

Bernardo Ortega, Paul A. Welling

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The transport functions of epithelial cells in the gastrointestinal (GI) tract, and elsewhere, are made possible by their remarkable apical-basolateral plasma membrane asymmetry. This property, commonly called membrane polarity, is achieved by a combination of intracellular trafficking operations, including sorting, vectorial delivery and membrane-specific docking, fusion and retention mechanisms. Here we provide a review of this rapidly evolving research field within a historically relevant context.

Original languageEnglish (US)
Title of host publicationPhysiology of the Gastrointestinal Tract
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Pages1027-1050
Number of pages24
Volume2-2
ISBN (Electronic)9780128124260
ISBN (Print)9780128099544
DOIs
StatePublished - Mar 28 2018
Externally publishedYes

Keywords

  • Adaptins
  • Epithelial polarity
  • Protein sorting
  • Rab GTPases
  • SNARES
  • Sorting signals

ASJC Scopus subject areas

  • Medicine(all)

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