Molecular mechanisms of peripheral benzodiazepine receptors

Solomon H Snyder, Maureen W. McEnery, Ajay Verma

Research output: Contribution to journalArticle

Abstract

Peripheral-type benzodiazepine receptors were identified initially as binding sites in peripheral tissues with markedly different drug specificity than the central type receptors. The density of peripheral receptors varies greatly among tissue with selective localization within organs. Steroid producing areas of glands, such as the adrenal, testes and ovary, are highly enriched in these receptors. Intracellular localizations provide further insight into function with peripheral receptors largely if not exclusively associated with outer membranes of mitochondria. Purification of the peripheral receptor protein from rat kidney mitochondria reveals two apparent subunits with molecular weights of about 30 and 18 kD respectively. This complex is functionally intact as determined by its ability to reversibly bink PK-11195 Ro5-4864, and PK-14105 with high affinity and specificity.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalNeurochemical Research
Volume15
Issue number2
DOIs
StatePublished - Feb 1990

Fingerprint

Mitochondria
GABA-A Receptors
Tissue
Purification
Testis
Rats
Ovary
Molecular Weight
Molecular weight
Steroids
Binding Sites
Membranes
Kidney
Pharmaceutical Preparations
Proteins
PK 14105
4'-chlorodiazepam
PK 11195

Keywords

  • [H]diazepam
  • Peripheral-type benzodiazepine receptors
  • Ro5-4864

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Molecular mechanisms of peripheral benzodiazepine receptors. / Snyder, Solomon H; McEnery, Maureen W.; Verma, Ajay.

In: Neurochemical Research, Vol. 15, No. 2, 02.1990, p. 119-123.

Research output: Contribution to journalArticle

Snyder, Solomon H ; McEnery, Maureen W. ; Verma, Ajay. / Molecular mechanisms of peripheral benzodiazepine receptors. In: Neurochemical Research. 1990 ; Vol. 15, No. 2. pp. 119-123.
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