Molecular mechanisms of olfactory neuronal gene regulation.

M. M. Wang, R. R. Reed

Research output: Contribution to journalReview articlepeer-review

Abstract

The mammalian olfactory system utilizes a biochemical cascade mediated by specialized proteins to detect odorants with high sensitivity and specificity. The recent identification of olfactory neuron-specific components for each step in the signalling cascade suggests that expression of these proteins is coordinately controlled by cis-acting regulatory sequences and trans-acting transcriptional activators. We have used molecular genetic methods to characterize sequences encoding tissue-specific DNA-binding sites in the genes for components of the odorant transduction pathway and have identified a putative transcription factor, Olf-1, that functions at these sites to regulate gene expression.

Original languageEnglish (US)
Pages (from-to)68-72; discussion 73-75, 88-7596
JournalCiba Foundation symposium
Volume179
StatePublished - 1993

ASJC Scopus subject areas

  • General

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