Molecular mechanisms of olfaction

Solomon H. Snyder, Pamela B. Sklar, Paul M. Hwang, Jonathan Pevsner

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent studies provide initial insights into molecular mechanisms of olfaction. The identification of an odorant-sensitive adenylate cyclase which responds to most odorants, affords a second messenger system following odorant interactions with receptors. Cyclic nucleotide- and odorant-gated ion channels have been demonstrated in olfactory cilia, providing signalling systems in place of or in addition to protein phosphorylation. A unique odorant-binding protein localized to nasal mucosa binds odorants in proportion to their odoriferous potencies. Molecular cloning of the isolated protein reveals it to be a member of a family of proteins that serve as carriers for small lipophilic molecules such as retinol and cholesterol. The odorant-binding protein is localized to lateral nasal glands whose secretions are atomized into the tip of the nose where the binding protein presumably interacts with odorants in the inspired air.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalTrends in neurosciences
Volume12
Issue number1
DOIs
StatePublished - Jan 1989

ASJC Scopus subject areas

  • Neuroscience(all)

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