Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

Ying Zhang; Douglas B. Young

doi:10.1016/0966-842X(93)90117-A

Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

Ying Zhang, Douglas B. Young

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.

Original language	English (US)
Pages (from-to)	109-113
Number of pages	5
Journal	Trends in Microbiology
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0966-842X(93)90117-A
State	Published - Jun 1993

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Infectious Diseases
Virology

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10.1016/0966-842X(93)90117-A

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title = "Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control",

abstract = "The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.",

author = "Ying Zhang and Young, {Douglas B.}",

note = "Funding Information: We are grateful to Drs Stewart Cole, Beate Heym, Jan van Embden and Dick van Soolingen for discussion and collaboration, and to Prof. Juraj Ivanyi for encouragement. Financial support was provided by a grant from the World Health Organization Programme for Vaccine Development.",

year = "1993",

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language = "English (US)",

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T2 - a drug at the front line of tuberculosis control

AU - Zhang, Ying

AU - Young, Douglas B.

N1 - Funding Information: We are grateful to Drs Stewart Cole, Beate Heym, Jan van Embden and Dick van Soolingen for discussion and collaboration, and to Prof. Juraj Ivanyi for encouragement. Financial support was provided by a grant from the World Health Organization Programme for Vaccine Development.

PY - 1993/6

Y1 - 1993/6

N2 - The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.

AB - The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.

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Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control

Abstract

ASJC Scopus subject areas

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