Abstract
The mechanisms responsible for differential cytokine expression in T helper (Th) cell subsets are still elusive. Nuclear factor of activated T cells (NFAT)-1 has been involved in activation of the interleukin (IL)-2 and IL-4 genes, which are expressed by Th1 and Th2 cells, respectively. On the other hand, we have identified two factors having opposite effects on the transcription of the IL-2 and IL-4 genes in the human T cell line Jurkat: nuclear factor (NF)-kB and CCAAT-binding protein (CP)2. We postulate that NF- kB and CP2 play important roles in differential cytokine display in Th cells and might be involved in the regulation of IL-4 expression in health and disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | International Journal of Immunopathology and Pharmacology |
| Volume | 10 |
| Issue number | 2 SUPPL. |
| State | Published - 1997 |
Keywords
- (NF)-kB
- Interleukin-4
- T helper cells
ASJC Scopus subject areas
- Pharmacology
Fingerprint Dive into the research topics of 'Molecular mechanisms of interleukin-4 production'. Together they form a unique fingerprint.
Cite this
Casolaro, V., Steindler, C., Ono, S. J., & Georas, S. N. (1997). Molecular mechanisms of interleukin-4 production. International Journal of Immunopathology and Pharmacology, 10(2 SUPPL.), 1-5.