Molecular mechanisms of interleukin-4 production

V. Casolaro, C. Steindler, S. J. Ono, S. N. Georas

Research output: Contribution to journalArticle

Abstract

The mechanisms responsible for differential cytokine expression in T helper (Th) cell subsets are still elusive. Nuclear factor of activated T cells (NFAT)-1 has been involved in activation of the interleukin (IL)-2 and IL-4 genes, which are expressed by Th1 and Th2 cells, respectively. On the other hand, we have identified two factors having opposite effects on the transcription of the IL-2 and IL-4 genes in the human T cell line Jurkat: nuclear factor (NF)-kB and CCAAT-binding protein (CP)2. We postulate that NF- kB and CP2 play important roles in differential cytokine display in Th cells and might be involved in the regulation of IL-4 expression in health and disease.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalInternational Journal of Immunopathology and Pharmacology
Volume10
Issue number2 SUPPL.
StatePublished - 1997

Keywords

  • (NF)-kB
  • Interleukin-4
  • T helper cells

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Molecular mechanisms of interleukin-4 production'. Together they form a unique fingerprint.

  • Cite this

    Casolaro, V., Steindler, C., Ono, S. J., & Georas, S. N. (1997). Molecular mechanisms of interleukin-4 production. International Journal of Immunopathology and Pharmacology, 10(2 SUPPL.), 1-5.