Abstract
The mechanisms responsible for differential cytokine expression in T helper (Th) cell subsets are still elusive. Nuclear factor of activated T cells (NFAT)-1 has been involved in activation of the interleukin (IL)-2 and IL-4 genes, which are expressed by Th1 and Th2 cells, respectively. On the other hand, we have identified two factors having opposite effects on the transcription of the IL-2 and IL-4 genes in the human T cell line Jurkat: nuclear factor (NF)-kB and CCAAT-binding protein (CP)2. We postulate that NF- kB and CP2 play important roles in differential cytokine display in Th cells and might be involved in the regulation of IL-4 expression in health and disease.
Original language | English (US) |
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Pages (from-to) | 1-5 |
Number of pages | 5 |
Journal | International Journal of Immunopathology and Pharmacology |
Volume | 10 |
Issue number | 2 SUPPL. |
State | Published - 1997 |
Keywords
- (NF)-kB
- Interleukin-4
- T helper cells
ASJC Scopus subject areas
- Pharmacology