Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

Farhoud Faraji; Munfarid Zaidi; Carole Fakhry; Daria A. Gaykalova

doi:10.1016/j.micinf.2017.06.001

Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

Farhoud Faraji, Munfarid Zaidi, Carole Fakhry, Daria A. Gaykalova

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.

Original language	English (US)
Pages (from-to)	464-475
Number of pages	12
Journal	Microbes and Infection
Volume	19
Issue number	9-10
DOIs	https://doi.org/10.1016/j.micinf.2017.06.001
State	Published - Sep 1 2017

Keywords

Chromatin
HNSCC
HPV
Oropharyngeal
Squamous cell carcinoma
Viral integration

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2017.06.001

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title = "Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer",

abstract = "This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.",

keywords = "Chromatin, HNSCC, HPV, Oropharyngeal, Squamous cell carcinoma, Viral integration",

author = "Farhoud Faraji and Munfarid Zaidi and Carole Fakhry and Gaykalova, {Daria A.}",

note = "Publisher Copyright: {\textcopyright} 2017 Institut Pasteur",

year = "2017",

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day = "1",

doi = "10.1016/j.micinf.2017.06.001",

language = "English (US)",

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journal = "Microbes and Infection",

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TY - JOUR

T1 - Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

AU - Faraji, Farhoud

AU - Zaidi, Munfarid

AU - Fakhry, Carole

AU - Gaykalova, Daria A.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.

AB - This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.

KW - Chromatin

KW - HNSCC

KW - HPV

KW - Oropharyngeal

KW - Squamous cell carcinoma

KW - Viral integration

UR - http://www.scopus.com/inward/record.url?scp=85021374852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021374852&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2017.06.001

DO - 10.1016/j.micinf.2017.06.001

M3 - Short survey

C2 - 28619685

AN - SCOPUS:85021374852

SN - 1286-4579

VL - 19

SP - 464

EP - 475

JO - Microbes and Infection

JF - Microbes and Infection

IS - 9-10

ER -

Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

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