Molecular mechanisms in allergy and clinical immunology: IL-11: Insights in asthma from overexpression transgenic modeling

Tao Zheng, Zhou Zhu, Jingming Wang, Robert J. Homer, Jack A. Elias

Research output: Contribution to journalArticle

Abstract

The evolution of our understanding of IL-11 mirrors, in many ways, the problems that are faced by investigators in the postgenome era and the types of techniques that might need to be used to deal with these issues. IL-11 was discovered as a soluble factor in fibroblast supernatants that stimulated the proliferation of "IL-6-dependent" plasmacytoma cells. It was subsequently demonstrated to be an important stimulator of platelet reconstitution and a pleiotropic regulator of nonrespiratory tissues. In the lung, IL-11 is produced by a variety of structural cells and eosinophils in response to a variety of stimuli, including TGF-β, major basic proteins, and viruses. IL-11 is also detected in exaggerated quantities at sites of virus infection. Its potential effector functions at these sites were defined with constitutive and inducible overexpression transgenic modeling systems which demonstrated that IL-11 causes nodular mononuclear infiltrates, airway remodeling with subepithelial fibrosis, airways obstruction, and airways hyperresponsiveness and can block alveolar development when expressed during development. In accord with these murine findings, IL-11 is selectively expressed in eosinophils and epithelial cells in patients with moderate and severe asthma where expression correlates directly with disease severity and inversely with FEV 1. Studies using transgenic mice also demonstrated that IL-11 inhibits antigen-induced tissue inflammation. Thus IL-11 might be an important regulator of inflammatory and remodeling responses in the asthmatic airway.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume108
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Interleukin-11
Allergy and Immunology
Asthma
Eosinophils
Airway Remodeling
Plasmacytoma
Virus Diseases
Airway Obstruction
Transgenic Mice
Interleukin-6
Fibrosis
Blood Platelets
Fibroblasts
Epithelial Cells
Research Personnel
Viruses
Inflammation
Antigens
Lung

Keywords

  • Airway remodeling
  • Asthma
  • Fibrosis
  • Interleukin 11
  • Transgenic modeling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Molecular mechanisms in allergy and clinical immunology : IL-11: Insights in asthma from overexpression transgenic modeling. / Zheng, Tao; Zhu, Zhou; Wang, Jingming; Homer, Robert J.; Elias, Jack A.

In: The Journal of Allergy and Clinical Immunology, Vol. 108, No. 4, 2001, p. 489-496.

Research output: Contribution to journalArticle

Zheng, Tao ; Zhu, Zhou ; Wang, Jingming ; Homer, Robert J. ; Elias, Jack A. / Molecular mechanisms in allergy and clinical immunology : IL-11: Insights in asthma from overexpression transgenic modeling. In: The Journal of Allergy and Clinical Immunology. 2001 ; Vol. 108, No. 4. pp. 489-496.
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